Bone Abstracts

Recent evidence suggests that osteoblastic bone marrow niche is vital for the maintenance and self-renewal of hematopoietic stem cells (HSC). It has been recently proposed that cholesterol efflux pathways participate in HSC mobilization and that cholesterol-sensing pathways control the proliferation of HSC progenitors. Moreover, we have recently documented that HDL perturbations result in impaired osteoblastic function in mice. In the present study, we aimed at investigating t...

Introduction: Recent data suggest that imbalances in lipid metabolism affect bone cell function resulting in osteoporosis. Here, we investigated the role of apolipoprotein E (ApoE), essential component of chylomicron and very low density Lipoprotein metabolic pathways, in the regulation of osteoblast and osteoclast function and thus in the pathogenesis of osteoporosis.Material and methods: We used apoE deficient (ApoE−/−) and wild ...

Introduction: Recent data suggest that imbalances in lipid metabolism affect the function of both osteoblasts and osteoclasts and thus bone quality. Here we investigated the role of apolipoprotein A-I (ApoA-I), a key-element of HDL biogenesis, in the regulation of cardinal genes/proteins that regulate lipoblasts and osteoblasts in mice.Materials and methods: We used apoA-I deficient (ApoA-I−/−) and wild-type (C57BL/6) mice (10 anim...